The Center of Excellence in Systems Microbiology (CESM), Faculty of Medicine, Chulalongkorn University aims to study and analyze infectious microbes (bacteria, fungus, and viruses) to gain novel fundamental knowledge and advanced research based on systems microbiology approaches. Our center contributes biomedical research publications with international standards and the development of creative medical innovations for the diagnosis, prevention, and treatment of infectious diseases in humans and animals. The CESM consisted of 4 branches, including. 

1) Metagenomics: focus on the classification of microbes based on targeted or shotgun high-throughput DNA sequencing to measure microbial diversity and relative abundance of each microbe in samples obtained from humans, animals, and environments.  

2) Microbial Genome: aim for genome assembly and gene annotation of various microbes based on next-generation sequencing (NGS) to reveal the crucial genes related to microbial characteristics such as infectivity, virulence, drug resistance, replication rate, immune escape, etc.  

3) Microbes & Host Response: seek out the molecular interactions between microbes and host cells based on multi-omics analysis (functional genomics, transcriptomics, proteomics, and metabolomics) for a better understanding of the pathogenesis and cellular response against infectious diseases leading to novel strategies for prevention and treatment.  

4) Pathogen Diagnosis: apply the advanced techniques in molecular biology to develop and innovate rapid, sensitive, specific, accurate, and cost-effective point-of-care detection kits for pandemic or epidemic pathogens.