Asst. Prof. Chaiyaboot Ariyachet, Ph.D.
Position: Lecturer
Email: Chaiyaboot.A@Chula.ac.th
Expertise:
- Stem cell and regenerative biology
- Cellular reprogramming for cell replacement theraphy
- Biology of non-coding RNAs
- Biology of gastrointestinal diseases
- Organoids for disease modeling and therapeutics
Biography
Assistant Professor Dr. Chaiyaboot Ariyachet was awarded a Ph.D. scholarship at Harvard Medical School, USA, for his doctoral degree in medical sciences. He also received a full scholarship from the Institute for the Promotion of Teaching Science and Technology (IPST) to pursue his bachelor’s degree in biology and graduated with a Summa Cum Laude. He was the recipient of several competitive international research grants, including those from the Asahi Glass Foundation, the Howard Hughes Medical Institute (HHMI), and the American Society for Microbiology (ASM). His PhD work presents a novel approach to treating type I diabetes and was published in Cell Stem Cell, the top journal in the field of stem cells and regenerative biology. This work was highlighted on the cover issue and won the best dissertation award from the National Research Council of Thailand. Dr. Ariyachet is currently an assistant professor and a researcher at the Center of Excellence in Hepatitis and Liver Cancers, Faculty of Medicine, Chulalongkorn University. His current work focuses on the roles of non-coding RNAs in liver diseases, including hepatocellular carcinoma (HCC) and liver fibrosis. Additionally, he is interested in transcriptional regulation in liver diseases. His recent work discovers the function of the novel transcription factor, ZNF469, which promotes liver fibrosis.
Education
- A.B. (Summa Cum Laude), Biology, Bowdoin College, USA, 2010
- Ph.D., Medical Sciences, Harvard Medical School, USA, 2016
Awards
- Travel Grant Award, The Liver Week 2023, Incheon, South Korea, 2023
- Asahi Glass Foundation, 2022
- Outstanding Dissertation Award (National Research Council of Thailand), 2021
- Merck Young Scientist Award, 2020
- Thai Representative at Lindau Nobel Laureate Meeting (Physiology and Medicine), 2018
- Harvard Stem Cell Institute (HSCI) Sternlicht Awards for Graduate Students, 2012
Publications
- Ariyachet, C.*, Nokkeaw, A., Boonkaew, B., & Tangkijvanich P. (2024) ZNF469 is a profibrotic regulator of extracellular matrix in hepatic stellate cells. Journal of Cellular Biochemistry (In Press) (Q1, IF = 4.000).
- Nokkeaw, A., Thamjamrassri, P., Chantaravisoot, N., Tangkijvanich, P., & Ariyachet, C.* (2023). Long Non-coding RNA H19 Promotes Proliferation in Hepatocellular Carcinoma Cells via H19/miR-107/CDK6 Axis. Oncology Research 31(6), 989–1005. (Q1, IF = 4.938)
- Nokkeaw, A., Thamjamrassri, P., Tangkijvanich, P., & Ariyachet, C.* (2023). Regulatory Functions and Mechanisms of Circular RNAs in Hepatic Stellate Cell Activation and Liver Fibrosis. Cells, 12(3), 378. (Q1, IF = 7.666)
- Ariyachet, C.*, Chuaypen, N., Kaewsapsak, P., Chantaravisoot, N., Jindatip, D., Potikanond, S., & Tangkijvanich, P. (2022). MicroRNA-223 Suppresses Human Hepatic Stellate Cell Activation Partly via Regulating the Actin Cytoskeleton and Alleviates Fibrosis in Organoid Models of Liver Injury. International Journal of Molecular Sciences, 23(16), 9380. (Q1, IF = 6.208)
- Ariyachet, C., Tovaglieri, A., Xiang, G., Lu, J., Shah, M.S., Richmond, C.A., Verbeke, C., Melton, D.A., Stanger, B.Z., Mooney, D., Shivdasani, R.A., Mahony, S., Xia, Q., Breault, D.T., & Zhou, Q. (2016) Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation. Cell Stem Cell 18(3), 401-421. (Cover article, Previewed in Cell Stem Cell, 295-297, Highlighted in Nature, Science, Science Translational Medicine, and Nature Reviews Endocrinology) (Q1, IF = 25.269)
- Ariyachet, C., Beißel, C., Li, X., Lorrey, S., Mackenzie, O., Martin, P. M., O’Brien, K., Pholcharee, T., Sim, S., Krebber, H. & McBride, A. E. (2017) Post-translational modification directs nuclear and hyphal tip localization of Candida albicans mRNA-binding protein Slr1. Molecular Microbiology, 104(3), 499–519. (Q1, IF = 3.804)
- Ariyachet, C., Solis, N.V., Liu, Y., Prasadarao, N.V., Filler, S.G., & McBride, A.E. (2013) SR-like RNA-binding protein Slr1 affects Candida albicans filamentation and virulence. Infection and Immunity 81(4), 1267-1276. (Q1, IF = 3.472)
Books
- Nokkeaw, A., Thamjamrassri, P., Tangkijvanich, P., & Ariyachet, C*. (2023). The Roles of Actin Cytoskeleton in Hepatic Stellate Cell Activation and Liver Fibrosis. Advances in Biology, Volume 4, 121-134. (Book Chapter)