Biochemistry

Asst. Prof. Natthaya Chuaypen, Ph.D.

Position: Lecturer

Expertise:

  • Molecular biology
  • Translation research

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Biography

        Asst. Prof. Natthaya Chuaypen is a lecturer and molecular biologist with several years of experience working in basic and translational research in hepatitis, liver cancer and chronic kidney disease at Department of Biochemistry, Faculty of Medicine, Chulalongkorn University. She pursued an MSc and Ph.D. in medical biochemistry from Chulalongkorn University after completing her BSc in medical science at Naresuan University. She completed her training as a PhD student at Storr Liver Center, The Westmead Institute for Medical Research, University of Sydney and Westmead Hospital, Sydney, Australia and Nagoya City University Graduate School of Medical Sciences and Medical school, Japan and earned international academic awards. She also completed her training as postdoctoral fellow at Center of Excellence in Hepatitis and Liver Cancer, Faculty of Medicine, Chulalongkorn University and National Cheng Kung University, Tainan, Taiwan.  

        She has published many peer-reviewed articles related to chronic hepatitis, liver cancer and gastroenterology. Her research has been focused on developing and applying molecular biology, which identify DNA, RNA and protein biomarkers and combing tools to integrate the clinical data, and gut microbiota profiles in chronic diseases. 

Education

  • Bachelor of Science in Medical Science, Faculty of Medical Science, Narasuan University, Thailand (2006-2010) 
  • Master’s degree in Medical Biochemistry, Faculty of Medicine, Chulalongkorn University, Thailand (2010-2012) 
  • Doctor of Philosophy Program in Medical Biochemistry, Faculty of Medicine, Chulalongkorn University, Thailand (2013-2016) 

Awards

  • Young Investigator Award by the Committee of the 29th Asian Pacific Association for the Study of the Liver (APASL) 2020 in Bali, Indonesia 
  • Young Investigator Bursary award [EASL-AASLD 2019] London, UK 
  • Travel Award for Outstanding Young Investigator [Asian Pacific Digestive Week 2016 (APDW 2016) Kobe, Japan, 2016] 
  • Young Investigator Award [25th Asian Pacific Association for the Study of the Liver (APASL), Tokyo, Japan, 2016] 
  • Outstanding Graduate Student Awards in doctoral degree, Chulalongkorn University, 2018 
  • Outstanding Graduate Student Awards in master’s degree, Chulalongkorn University, 2014 

Publications

  1. Chuaypen N, Asumpinawong A, Sawangsri P, Khamjerm J, Iadsee N, Jinato T, Sutheeworapong S, Udomsawaengsup S, Tangkijvanich P. Gut Microbiota in Patients with Non-Alcoholic Fatty Liver Disease without Type 2 Diabetes: Stratified by Body Mass Index. Int J Mol Sci. 2024 Feb 2;25(3):1807.
  2. Chuaypen N, Jinato T, Avihingsanon A, Nookaew I, Tanaka Y, Tangkijvanich P. Long-term benefit of DAAs on gut dysbiosis and microbial translocation in HCV-infected patients with and without HIV coinfection. Sci Rep. 2023 Sep 2;13(1):14413.
  3. Teengam P, Tangkijvanich P, Chuaypen N*, Chailapakul O*. An innovative wireless electrochemical card sensor for field-deployable diagnostics of Hepatitis B surface antigen. Sci Rep. 2023 Mar 2;13(1):3523.
  4. Kunadirek P, Pinjaroen N, Nookaew I, Tangkijvanich P, Chuaypen N. Transcriptomic Analyses Reveal Long Non-Coding RNA in Peripheral Blood Mononuclear Cells as a Novel Biomarker for Diagnosis and Prognosis of Hepatocellular Carcinoma. International Journal of Molecular Sciences. 2022 Jan;23(14):7882.
  5. Jinato T, Chayanupatkul M, Dissayabutra T, Chutaputti A, Tangkijvanich P, Chuaypen N. Litchi-Derived Polyphenol Alleviates Liver Steatosis and Gut Dysbiosis in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Double-Blinded, Placebo-Controlled Study. Nutrients. 2022 Jan;14(14):2921.
  6. Chuaypen N, Limothai U, Kunadirek P, Kaewsapsak P, Kueanjinda P, Srisawat N, Tangkijvanich P. Identification and validation of circulating miRNAs as potential new biomarkers for severe liver disease in patients with leptospirosis. PLoS One. 2021 Sep 27;16(9):e0257805.
  7. Chuaypen N, Jinato T, Avihingsanon A, Chirapongsathorn S, Cheevadhanarak S, Nookaew I, Tanaka Y, Tangkijvanich P. Improvement of Gut Diversity and Composition after Direct-Acting Antivirals in HCV-Infected Patients with or without HIV Coinfection. J Infect Dis. 2021 Feb 17:jiab094.

Books

  • ณัฐธยาน์ ช่วยเพ็ญ “โครงสร้างและหน้าที่ของคาร์โบไฮเดรต” หลักชีวเคมีทางการแพทย์ หน้า 15-25 กรุงเทพฯ: สนักพิมพ์จุฬาลงกรณ์มหาวิทยาลัย พ.ศ. 2563-2566
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